Nurr1 agonist 12

SKU: orb3028936

Description

Nurr1 agonist 12 (Compound 37) acts as an agonist of the nuclear receptor-related protein 1 (Nurr1), enhancing its transcriptional activity with an EC50 of 0.06 μM. It stimulates human response elements NBRE, NurRE, and DR5 with EC50 values of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Additionally, Nurr1 agonist 12 induces the expression of neurotrophic genes regulated by Nurr1, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). The compound also demonstrates neuroprotective effects against neurotoxicity caused by Paraquat.

Research Area

Cancer Biology; Pharmacology & Drug Discovery, Metabolism Research

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Key Properties

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MW	321.76
Formula	C₁₈H₁₂ClN₃O
SMILES	O=C(C1=C(Cl)C=C(C=CN2)C2=C1)NC3=CC4=CC=CC=C4N=C3
Target	NR4A

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

NR4A

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Nurr1 agonist 12

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