Cart summary

You have no items in your shopping cart.

NX-2127

SKU: orb1744147

Description

NX-2127 is an orally bioavailable BTK inhibitor that degrades mutant BTKC481S and the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). It demonstrates potent antiproliferative effects in B-cell lymphoma models and has immunomodulatory activity, enhancing T-cell activation and IL-2 production in vitro.

Research Area

Cardiovascular Research, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2416131-46-7
MW719.83
Purity99.07%
FormulaC39H45N9O5
SMILESO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=C(C2)N4C[C@H](CN5CCC(CC5)C6=CC=C(NC=7C(C(N)=O)=NC=C(N7)N8CCCCC8)C=C6)CC4
TargetIKZF,BTK,PROTACs
Solubility2% DMSO+40% PEG300+5% Tween 80+53% Saline:3 mg/mL (4.17 mM);DMSO:150 mg/mL (208.38 mM)

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BTK, NX 2127, NX2127, NX-2127

Similar Products

Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

NX-2127 (orb1744147)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 150.00
5 mg
$ 300.00
10 mg
$ 430.00
25 mg
$ 760.00
50 mg
$ 1,030.00
100 mg
$ 1,400.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry