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OG-L002

SKU: orb1226457

Description

OG-L002 is a novel selective LSD1 inhibitor with IC50 of 20 nM; demonstrates significant potency both in inhibition of HSV IE gene expression and in suppression of viral reactivation from latency in a mouse ganglion explant model; also suppresses the expression of the initial class of hCMV and adenovirus genes in vitro; reduces the induction of TNF-α mRNA in splenocytes from mice.

Images & Validation

Key Properties

CAS Number1357302-64-7
MW225.3
Purity>98% (HPLC)
FormulaC15H15NO
SMILESOC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1
TargetHistone Demethylase
SolubilityDMSO: 42 mg/mL (186.4 mM); Ethanol: 16 mg/mL (71 mM); Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

In Vivo
OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection. Animal model: 4-week-old BALB/c female mice. Dosage: 6, 20, 40 mg/kg. Administration: Intraperitoneal; daily; for 7 days. Result: Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection.
In Vitro
OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC50 (IC50: ~10 μM in HeLa cells; IC50: ~3 μM in HFF cells) relative to the control MAOI TCP (IC50: ~1 mM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

OG L002

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OG-L002 (orb1226457)

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Available Sizes

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2 mg
$ 110.00
5 mg
$ 160.00
10 mg
$ 260.00
25 mg
$ 440.00
50 mg
$ 710.00
100 mg
$ 1,000.00
500 mg
$ 1,980.00