OG-L002

SKU: orb1301098

Description

OG-L002 is a potent and selective LSD1 inhibitor with an IC50 of 20 nM, demonstrating 69-fold and 36-fold selectivity against MAO-A and MAO-B, respectively. It is a valuable chemical probe for studying epigenetic regulation in cancer research and has been utilized in both cellular and animal models of leukemia and solid tumors.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Neuroscience

Images & Validation

−

Key Properties

−

CAS Number	1357302-64-7
MW	225.29
Purity	97.05%
Formula	C₁₅H₁₅NO
SMILES	N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(O)c1
Target	HSV,Histone Demethylase,Monoamine Oxidase
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.44 mM);Ethanol:16 mg/mL (71.02 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (244.13 mM)

Bioactivity

−

Target IC50	LSD1:20 nM
In Vivo	OG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model. Read more...
In Vitro	OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene. Read more...
Cell Research	HeLa or HFF cells are treated with the indicated concentrations of saponin (positive control) or compound OG-L002 for 12 hours. Cytotoxicity is determined using conditions recommended by the manufacturer and expressed as ratios to the cytotoxicity of the DMSO control.(Only for Reference) Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Herpes simplex virus, MAO, MAO-A, MAO-B, MonoamineOxidase, Monoamine Oxidase, monoamine, HistoneDemethylase, Histone Demethylase, HSV, OG L002, OG-L 002, OGL002, OG-L002, OG-L-002, oxidases, LSD1, inhibit, Inhibitor

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

56639570 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

OG-L002 (orb1301098)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	1357299-45-6
MW:	261.75
Formula:	C₁₅H₁₆ClNO

Purity:	>98% (HPLC)
CAS Number:	1357302-64-7
MW:	225.3
Formula:	C₁₅H₁₅NO

OG-L002

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

OG-L002 hydrochloride [orb2664184]

OG-L002 [orb1226457]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

OG-L002 (orb1301098)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors