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Ombuin

SKU: orb1297259

Description

Ombuin is a bioactive small molecule with demonstrated anti-inflammatory properties, functioning through the inhibition of specific pro-inflammatory macrophage activities. It is utilized in research to study inflammation mechanisms in both cellular and animal models.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number529-40-8
MW330.29
Purity98.85%
FormulaC17H14O7
SMILESCOc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(O)c2=O
TargetAntibacterial
SolubilityDMSO:60 mg/mL (181.66 mM)

Bioactivity

Target IC50
Antibacterial:125- 500 μg/mL(MIC)
In Vitro
Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose-dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

broad, armatum, Bacterial, antibacterial, IL Receptor, Inhibitor, inhibit, NO Synthase, Ombuin, spectrum, TNF-α, Zanthoxylum

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Key Properties

No computed properties available.

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Ombuin (orb1297259)

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Available Sizes

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1 mg
$ 80.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 240.00
25 mg
$ 390.00
50 mg
$ 560.00
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