Onalespib

SKU: orb1300903

Description

Onalespib (AT13387) is an orally available small molecule Hsp90 inhibitor with antineoplastic potential. It disrupts Hsp90's chaperone function, leading to the degradation of client oncoproteins critical for tumor survival. This compound has demonstrated activity in preclinical studies across various cancer models, supporting its investigation in oncology research.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	912999-49-6
MW	409.52
Purity	99.01%
Formula	C₂₄H₃₁N₃O₃
SMILES	CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O
Target	HSP
Solubility	DMSO:2.04 mg/mL (4.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM)

Bioactivity

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Target IC50	HSP90 (AT13387):18 nM
In Vivo	AT13387 is a potent inhibitor of the proliferation and survival of many different cell lines from a wide range of different tumor types (e.g., MES-SA cell line). In a panel of 30 tumor cell lines, AT13387 effectively inhibited cell proliferation with GI50 values in the range of 13-260 nM. AT13387 inhibited the proliferation of the non-tumorigenic human prostate epithelial cell line PNT2 with a GI50 value of 480 nM. Read more...
In Vitro	AT13387 is a potent inhibitor of the proliferation and survival of many different cell lines from a wide range of different tumor types (e.g., MES-SA cell line). In a panel of 30 tumor cell lines, AT13387 effectively inhibited cell proliferation with GI50 values in the range of 13-260 nM. AT13387 inhibited the proliferation of the non-tumorigenic human prostate epithelial cell line PNT2 with a GI50 value of 480 nM. Read more...
Cell Research	The human cell lines including A375, 22RV1, T474, DU1 45, LNCa P, MCF-7, DA-MB-468 are seeded into 96-well plates before the addition of AT13387 in 0.1% (v/v) DMSO. GI50 are determined using a 10-point dose response curve for three cell doubling times. After AT13387 incubation 10% (v/v), Alamar blueis added, and cells are incubated for a further 4 hours. Fluorescence is read.(Only for Reference) Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AT 13387, AT13387, AT-13387, Onalespib, Onalespib (AT13387), inhibit, HSP, HSP90, Inhibitor, Heat shock proteins

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Compound Identifiers

PubChem CID

11955716 ↗

Key Properties

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No computed properties available.

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Protocol Information

Find More Protocols

Romy Cools # 1, Valeria Narykina # 1 2 3, Koen Vermeulen 4, Sanket J Mishra 5, Brian S J Blagg 5 6, Marleen Derweduwe 7 8 9, Frederik De Smet 7 8 9, Aaron Ziani-Zeryouh 10, Matteo Riva 10 11, An Coosemans 10, Frederic Rousseau 2 3, Joost Schymkowitz 2 3, Guy Bormans 12 [11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics EJNMMI Radiopharm Chem, (2025)

PubMed: 41003947

Onalespib (orb1300903)

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CAS Number:	1019889-35-0
MW:	499.6
Formula:	C₂₇H₃₇N₃O₆

Onalespib

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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