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ONX-0914

SKU: orb1301137

Description

ONX-0914 (PR-957) is a potent and selective inhibitor of the immunoproteasome, demonstrating low activity against constitutive proteasome subunits. This small molecule is widely used in both in vitro and in vivo research to study autoimmune diseases, inflammation, and cancer immunotherapy mechanisms.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number960374-59-8
MW580.67
Purity98.47%
FormulaC31H40N4O7
SMILESCOc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
TargetProteasome,HIV Protease,Antibacterial
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.44 mM);DMSO:140 mg/mL (241.1 mM)

Bioactivity

Target IC50
Immunoproteasome:~10 nM
In Vivo
In mouse models of rheumatoid arthritis and lupus, the maximum tolerated dose (MTD) of ONX-0914 in mice to be 30 mg/kg body weight.
In Vitro
Selective inhibition of LMP7 by PR-957 blocked production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Bacterial, ONX 0914, ONX0914, ONX-0914, Inhibitor, inhibit, Human immunodeficiency virus, HIV, HIVProtease, HIV Protease, Proteasome, PR957, PR-957, PR 957

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Key Properties

No computed properties available.

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Protocol Information

ONX-0914 (orb1301137)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 200.00
10 mg
$ 240.00
25 mg
$ 380.00
50 mg
$ 540.00
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