Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

OSS-128167

SKU: orb1223743

Description

OSS-128167 is a novel selective, cell permeable SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively; increases H3K9 acetylation and GLUT-1 expression in treated cells.

Images & Validation

Key Properties

CAS Number887686-02-4
MW366.329
Purity>98% (HPLC)
FormulaC19H14N2O6
SMILESC1=CC(NC(=O)C2=CC=CO2)=CC(C(=O)NC2=CC=C(O)C(C(O)=O)=C2)=C1
TargetSirtuin
SolubilityDMSO: 68 mg/mL (185.6 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

In Vivo
Animal model: Male HBV transgenic mice (6-8-week-old). Dosage: 50 mg/kg. Administration: Intraperitoneal injection; every 4 days; for 12 days. Result: The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice.
In Vitro
Western blot analysis. Cell line: BxPC3 cells. Concentration: 100 μM. Incubation time: 0 hours, 2 hours, 6 hours, 18 hours, 24 hours. Result: Increased H3K9 acetylation. RT-PCR Cell line: HepG2.2.15 and HepG2-sodium taurocholate cotransporting polypeptide (NTCP) cells Concentration: 100 μM. Incubation time: 96 hours. Result: Significantly decreased HBV core DNA and 3.5-Kb RNA levels.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

OSS128167

Similar Products

  • OSS-128167 [orb1302947]

    >98%

    887686-02-4

    366.3

    C19H14N2O6

    5 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

OSS-128167 (orb1223743)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 190.00
25 mg
$ 350.00
50 mg
$ 610.00
100 mg
$ 890.00
500 mg
$ 1,850.00