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OSS-128167

SKU: orb1302947

Description

OSS_128167 (SIRT6-IN-1) is a selective SIRT6 inhibitor with an IC50 of 89 µM, demonstrating over 17-fold selectivity against SIRT1 and SIRT2. This compound is a valuable chemical probe for investigating SIRT6 biology in cellular and biochemical assays related to aging, metabolism, and genomic stability.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number887686-02-4
MW366.3
Purity>98%
FormulaC19H14N2O6
SMILESOC(=O)c1cc(NC(=O)c2cccc(NC(=O)c3ccco3)c2)ccc1O
TargetProtein deacetylase
SolubilitySoluble in DMSO (25 mg/ml); or Ethanol (25 mg/ml)

Bioactivity

Target IC50
SIRT1 (cell-free assay):1578 μM|SIRT6 (cell-free assay):89 μM|SIRT2 (cell-free assay):751 μM
In Vitro
OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6.
Cell Research
BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TNF-α, PPARα, SIRT2, SIRT1, Sirtuin, SIRT6, SIRT6-IN-1, OSS_128167, immune, inhibit, Inhibitor, Hepatitis B virus, HBV, H3K9, GLUT-1, deacetylase, chemosensitization, diabetes, acetylation, antiviral, anti-cancer

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  • OSS-128167 [orb1223743]

    >98% (HPLC)

    887686-02-4

    366.329

    C19H14N2O6

    1 g, 500 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 5 mg
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Key Properties

No computed properties available.

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OSS-128167 (orb1302947)

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% DMSO +
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% Tween 80 +
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5 mg
$ 200.00
25 mg
$ 400.00
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