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OSS_128167

SKU: orb1302947

Description

OSS_128167 (SIRT6-IN-1) is a selective SIRT6 inhibitor with an IC50 of 89 µM, demonstrating over 17-fold selectivity against SIRT1 and SIRT2. This compound is a valuable chemical probe for investigating SIRT6 biology in cellular and biochemical assays related to aging, metabolism, and genomic stability.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology

Images & Validation

Key Properties

CAS Number887686-02-4
MW366.32
Purity99.25%
FormulaC19H14N2O6
SMILESOC(=O)c1cc(NC(=O)c2cccc(NC(=O)c3ccco3)c2)ccc1O
TargetSirtuin,HBV
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.46 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:50 mg/mL (136.49 mM)

Bioactivity

Target IC50
SIRT1 (cell-free assay):1578 μM|SIRT6 (cell-free assay):89 μM|SIRT2 (cell-free assay):751 μM
In Vitro
OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6.
Cell Research
BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TNF-α, PPARα, SIRT2, SIRT1, Sirtuin, SIRT6, SIRT6-IN-1, OSS_128167, immune, inhibit, Inhibitor, Hepatitis B virus, HBV, H3K9, GLUT-1, deacetylase, chemosensitization, diabetes, acetylation, antiviral, anti-cancer
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

OSS_128167 (orb1302947)

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% DMSO +
%+
% Tween 80 +
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Available Sizes

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1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 130.00
5 mg
$ 130.00
10 mg
$ 160.00
25 mg
$ 290.00
50 mg
$ 430.00
100 mg
$ 630.00
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