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Osthenol

SKU: orb1297544

Description

Osthenol is a natural coumarin derivative that acts as a selective, reversible, and competitive inhibitor of human monoamine oxidase A (hMAO-A) with a Ki of 0.26 µM. It exhibits research utility in neuropharmacology and oncology due to its antitumor-promoting, antifungal, and antibacterial activities demonstrated in vitro.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number484-14-0
MW230.26
Purity98.33% (May vary between batches)
FormulaC14H14O3
SMILESCC(C)=CCc1c(O)ccc2ccc(=O)oc12
TargetMAO,Akt,PI3K,Monoamine Oxidase,Apoptosis
SolubilityDMSO:30 mg/mL (130.29 mM)

Bioactivity

Target IC50
MAO-A (human):0.26 µM (Ki)|MAO-A (human):0.74 μM
In Vitro
The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytoxic activities by MTT method. Eleven compounds were isolated and identified as osthole (1), bergaptan (2), xanthotoxol (3), xanthotoxin (4), imperatorin (5), isopimpinellin (6), Osthenol (7), psoralen (8), 5,7-dimethoxycoumarin (9), oxypeucedaninhydrate (10), and swietenocoumarin F (11). Compounds 7, 9-11 were isolated from the Cnidium genus for the first time

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

selective, Antifection, depression, coumarin, competitive, Inhibitor, hMAO-A, MAO-A, MAO, inhibit, Monoamine Oxidase, MonoamineOxidase, Osthenol, Ostenol

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  • Osthenol [orb1219413]

    >98% (HPLC)

    484-14-0

    230.26

    C14H14O3

    200 mg, 100 mg, 5 mg, 50 mg, 25 mg, 10 mg, 1 g, 500 mg
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Key Properties

No computed properties available.

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Osthenol (orb1297544)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 140.00
5 mg
$ 240.00
1 ml x 10 mM (in DMSO)
$ 260.00
10 mg
$ 340.00
25 mg
$ 540.00
50 mg
$ 760.00
100 mg
$ 1,030.00
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