Cart summary

You have no items in your shopping cart.

Otenabant

SKU: orb1304116

Description

Otenabant (CP-945598) is a selective cannabinoid CB1 receptor antagonist researched for obesity treatment. It has been utilized in both in vitro binding assays and in vivo animal studies to investigate energy homeostasis and metabolic pathways.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number686344-29-6
MW510.42
Purity100.00%
FormulaC25H25Cl2N7O
SMILESCCNC1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)C(N)=O
TargetCannabinoid Receptor
SolubilityDMSO:10 mg/mL (19.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.96 mM)

Bioactivity

Target IC50
CB:0.7 nM(Ki)
In Vivo
Otenabant effectively enhances energy expenditure and promotes fat oxidation in rats, alongside reducing the respiratory quotient, indicative of a shift towards greater fat utilization. When administered orally at a dosage of 10 mg/kg, Otenabant results in a notable 9% weight reduction over 10 days in mice with diet-induced obesity, after adjusting for vehicle effects. Additionally, Hydrochloride (HCl) form of Otenabant counteracts behaviors induced by cannabinoid agonists—including altered locomotor activity, hypothermia, analgesia, and catalepsy—triggered by the synthetic CB1 receptor agonist CP-55940. Furthermore, in rodent models, Otenabant HCl demonstrates a dose-dependent appetite-suppressing effect and increases both energy expenditure and fat oxidation.
In Vitro
Otenabant HCl has a low Ki affinity for human CB2 receptors of 7.6 μM. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cannabinoid Receptor, CannabinoidReceptor, CB1, CB, CP 945598, CP945598, CP-945598, inhibit, Otenabant, Inhibitor

Similar Products

  • Otenabant hydrochloride [orb1307424]

    99.79%

    686347-12-6

    546.88

    C25H26Cl3N7O

    25 mg, 50 mg, 2 mg, 5 mg, 10 mg, 1 mg, 100 mg
  • Otenabant hydrochloride [orb1224244]

    >98% (HPLC)

    686347-12-6

    546.9

    C25H26Cl3N7O

    200 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 10 mg, 1 g, 500 mg
  • Otenabant [orb1224245]

    >98% (HPLC)

    686344-29-6

    510.4

    C25H25Cl2N7O

    1 g, 500 mg, 200 mg, 100 mg, 25 mg, 2 mg, 5 mg, 10 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Otenabant (orb1304116)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 110.00
25 mg
$ 180.00
50 mg
$ 270.00
100 mg
$ 410.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry