OTUD5 Antibody / DUBA

SKU: orb248139

Description

OTUD5 (ovarian tumor domain-containing 5), also called DUBA (Deubiquitinating enzyme A), is a product of the OTUD5 gene, and a suppressor of the innate immune response via its deubiquitinating activity. The Innate immune systems provide immediate but short-lived defense against infection identified by PRRs, or pattern recognition receptors. OTUD5 cleaves the lysine-63-linked polyubiquitin chains of TRAF3, causing it to dissociate from TBK1, thereby failing to stimulate IFN type 1 production and leading to a suppressed innate immune response.

Images & Validation

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Tested Applications	WB
Dilution range	Western blot: 2-5ug/ml
Reactivity	Human, Mouse, Rat
Application Notes	Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Key Properties

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Antibody Type	Primary Antibody
Host	Rabbit
Clonality	Polyclonal
Isotype	Rabbit IgG
Immunogen	A recombinant protein fragment from the C-terminal region of human OTUD5 was used as the immunogen for this antibody.
Purification	Protein A affinity chromatography
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	1X PBS, pH 7.4
Disclaimer	For research use only

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Western blot testing of human samples with OTUD5 antibody at 2 ug/ml.

Western blot testing of mouse samples with OTUD5 antibody at 4 ug/ml.

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Protocol Information

Western Blot (IB, immunoblot)

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