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Oxymatrine

SKU: orb1305067

Description

Oxymatrine is a bioactive alkaloid derived from Sophora flavescens with demonstrated research applications. It exhibits antiviral activity against hepatitis B and has been studied in vitro and in vivo for its ability to modulate inflammatory pathways, including the inhibition of iNOS and the TGF-β/Smad signaling cascade.

Research Area

Cell Biology, Infectious Disease & Virology, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number16837-52-8
MW264.36
Purity99.84% (May vary between batches)
FormulaC15H24N2O2
SMILESO=N12[C@@]3([C@@]([C@@]4(N(C[C@@]3(CCC1)[H])C(=O)CCC4)[H])(CCC2)[H])[H]
TargetInfluenza Virus,Apoptosis,TGF-beta/Smad,Autophagy
SolubilityDMSO:125 mg/mL (472.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.13 mM);H2O:33.33 mg/mL (126.08 mM)

Bioactivity

In Vivo
LD50 in mouse: 521 mg/kg, i.p.
Cell Research
DU145, PC-3 and PNT1B cell lines (3×104 cells/well) are seeded into 96-well plates and incubated overnight at 37°C in 5% CO2. Subsequently, the cells are incubated with different concentrations of oxymatrine (0, 2, 4, 6 and 8 mg/mL). MTT (10 mL; 5 mg/mL) is added and the mixture is incubated in darkness at 37°C for 2 h. Absorbance is measured at a wavelength of 490 nm using a microplate reader.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Autophagy, Oxymatrine, Oxysophoridine, Influenza Virus, InfluenzaVirus, inhibit, Inhibitor, Matrine N-oxide, Smad, TGF-β/Smad, TGF-beta/Smad, TGFβ, TGF-beta, TGFbeta/Smad, TGF-b/Smad, TGFbeta, TGFb, Transforming growth factor beta

Similar Products

  • Oxymatrine (Standard) [orb3140819]

    16837-52-8

    264.36

    C15H24N2O2

    25 mg
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Key Properties

No computed properties available.

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Oxymatrine (orb1305067)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

50 mg
$ 90.00
100 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
200 mg
$ 130.00
500 mg
$ 170.00
1 g
$ 220.00
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