Ozoralizumab Antibody

SKU: orb1980322

Description

Ozoralizumab (ATN-103) is a humanized, bispecific nanobody that inhibits TNFα and binds serum albumin to extend half-life. It is a research tool for studying rheumatoid arthritis pathogenesis and has been utilized in both in vitro binding assays and in vivo animal models of inflammatory disease.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	1167985-17-2
MW	38.44 kDa
Purity	95.6% (SEC-HPLC)
Target	TNF

Bioactivity

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In Vivo

METHODS: Tg197 mice were injected subcutaneously with 1 mg/kg dose of Ozoralizumab (ATN-103) twice weekly to evaluate the formation of ADA against each anti-TNFα antibody and the effect of long-term administration of these anti-TNFα antibodies on TNFα-mediated TNFα in Tg197 mice. Efficacy of polyarthritis. RESULTS: Ozoralizumab (ATN-103) significantly and comparably reduced arthritis scores.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ATN-103, TNF-α, TS-152

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Gene Symbol

TNF

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