Paeoniflorin-6′-O-benzene sulfonate

SKU: orb3028935

Description

Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1390658-79-3
MW	620.622
Formula	C₂₉H₃₂O₁₃S
SMILES	C(OC(=O)C1=CC=CC=C1)[C@@]23[C@@]4(O[C@@H]5O[C@H](COS(=O)(=O)C6=CC=CC=C6)[C@@H](O)[C@H](O)[C@H]5O)[C@@]7(C)O[C@@]2(O[C@@](O)([C@@]3(C4)[H])C7)[H]
Target	STAT,Interleukin,TNF,IFNAR,JAK,GRK,CXCR

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

STAT,Interleukin,TNF,IFNAR,JAK,GRK,CXCR

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