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Palmitic acid

SKU: orb1304861

Description

Palmitic acid, a ubiquitous saturated fatty acid present across biological kingdoms, exhibits documented antitumor properties. It is widely utilized in biochemical research to study lipid metabolism, cancer biology, and as a key component in both in vitro cell culture studies and in vivo metabolic research models.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

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Palmitic acid

Key Properties

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CAS Number57-10-3
MW256.42
Purity99.87% (May vary between batches)
FormulaC16H32O2
SMILESC(CCCCCCCCCC)CCCCC(O)=O
TargetEndogenous Metabolite,HSP
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:0.26 mg/mL (1.01 mM);DMSO:100 mg/mL (389.99 mM);Ethanol:40.83 mg/mL (159.23 mM)

Bioactivity

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Target IC50
Colo-320-DM cells:0.35 µg/mL|Caco-2 cells:0.75 µg/mL|MCF-7 cells:0.55 µg/mL|WRL-68 cells:1 µg/mL
In Vivo
METHODS: To investigate the effects on adverse biological behaviors in mice, Palmitic acid (0.3-30 μmol/mouse in castor oil) was administered as a single intraperitoneal injection to C57BL/6J mice, and biological behaviors were analyzed 2-24 h later. RESULTS: In a dose-dependent manner, Palmitic acid rapidly reduced locomotor activity in mice through a mechanism dependent on fatty acid chain length. 24 h after Palmitic acid administration, mice exhibited anxiety-like behaviors, whereas there was no impairment of locomotion, food intake, depression-like behaviors, or spatial memory. METHODS: To investigate the effects on myocardial injury, Palmitic acid (5 mM in 500 μL solution) was injected intravenously into the tail of wild-type C57BL/6 (B6) and Md2-/- (KO) mice once a day for seven days. RESULTS: Palmitic acid induced myocardial inflammatory injury via TLR4 accessory protein MD2 and protected Md2 knockout mice from myocardial injury induced by Palmitic acid and high-fat diet.
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In Vitro
METHODS: Mouse microglia BV2 were treated with Palmitic acid (25-200 nM) for 6-48 h, and cell viability was measured by MTT. RESULTS: Palmitic acid had concentration- and time-dependent inhibitory effects on microglia viability. METHODS: Monocyte-derived dendritic cells MoDC were treated with Palmitic acid (150 μM) for 12 h. The expression of DC co-stimulatory factors was measured by Flow Cytometry. RESULTS: Palmitic acid induced the expression of CD86 and CD83, indicating that the activation and maturation of MoDC were induced simultaneously.
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Cell Research
Cell Experiment Solubilisation Formula: 1. Dissolve 1 mg of palmitic acid in 78 μL of anhydrous ethanol to obtain a 50 mM stock solution; if a higher concentration is required, dissolve 1 mg of palmitic acid in 39 μL of anhydrous ethanol to obtain a 100 mM stock solution. 2. Prepare a 10% BSA solution using culture medium (e.g., DMEM); BSA without fatty acids is preferable, with a concentration of 100 mg/mL. 3. For the solvent control group, prepare ethanol and BSA control solutions at the corresponding concentrations without lipids. 4. As an example of preparing 1 mL of a 0.25 mM working solution, mix 5 μL of 50 mM palmitic acid stock solution + 100 μL of 10% BSA solution + 895 μL of culture medium. The final solution will contain 1% BSA. The ethanol concentration should be controlled between 0.1%~0.5%. 5. Filter the working solution using a sterile filter membrane for use in cell processing.
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Inhibitor, inhibit, Palmitic acid, hexadecanoic acid, Hexadecoic acid, Heat shock proteins, EndogenousMetabolite, Endogenous Metabolite, HSP, Cetylic acid

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Compound Identifiers

PubChem CID
985 ↗

Key Properties

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No computed properties available.

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Palmitic acid (orb1304861)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
5 g
$ 90.00
10 g
$ 110.00
25 g
$ 140.00
50 g
$ 190.00
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