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PCC0105005

SKU: orb3174495

Description

PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and 5-HT1F Receptor partial agonist (EC50 = 77.91 nM). It demonstrates significant efficacy in rat models of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins while inhibiting the phosphorylation levels of ERK and CREB. This compound is useful for migraine research.

Research Area

Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2921670-99-5
MW894.14
FormulaC51H63N11O4
SMILESN(C(=O)C=1C=C2C(=CC1)NC(=O)C(=C2)C3CCN(C(N[C@H](CC=4C=C5C(=C(C)C4)NN=C5)C(=O)N6CCN(CC6)C7CCN(C)CC7)=O)CC3)C=8C=C9C(=CNC9=CC8)C%10CCN(C)CC%10
Target5-HT Receptor,CGRP Receptor,ERK,Epigenetic Reader Domain

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information