PD-1 mAb (29F.1A12)TM, InVivoPure+

Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its ligand, programmed death-ligand 1 (PD-L1), activates downstream signaling pathways and inhibits T cell activation. Moreover abnormally high PD-L1 expression on tumor cells and antigen-presenting cells in the tumor microenvironment mediates tumor immune escape, and the development of anti-PD-1/PD-L1 antibodies has recently become a hot topic in cancer immunotherapy. The 29F.1A12 antibody is a monoclonal antibody directed against the mouse protein PD-1 (Programmed Death-1), also known as CD279. It blocks the binding of PD-1 to its two ligands, PD-L1 and PD-L2.