Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Peficitinib

SKU: orb1300333

Description

Peficitinib

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number944118-01-8
MW326.39
Purity98.67% (May vary between batches)
FormulaC18H22N4O2
SMILES[H][C@]12CC3C[C@]([H])(CC(O)(C3)C1)C2Nc1c(cnc2[nH]ccc12)C(N)=O
TargetJAK,Tyrosine Kinases
SolubilityH2O:<1 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.13 mM);Ethanol:<1 mg/mL;DMSO:60 mg/mL (183.83 mM)

Bioactivity

Target IC50
TYK2:4.8 nM|JAK2:5.0 nM|JAK1:3.9 nM|JAK3:0.7 nM
In Vivo
In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score.
In Vitro
ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

rheumatoid arthritis, splenocytes, Tyk2, TyrosineKinases, Tyrosine Kinases, ASP015K, inhibit, JAK3, Janus kinase, JAK2, JAK, JAK1, JNJ54781532, JNJ-54781532, JNJ 54781532, Peficitinib, lymphocytes, Inhibitor, IL-2

Similar Products

  • Peficitinib hydrobromide [orb1695731]

    1353219-05-2

    407.312

    C18H23BrN4O2

    50 mg, 100 mg, 25 mg
  • Peficitinib hydrochloride [orb1688672]

    1353219-06-3

    362.86

    C18H23ClN4O2

    50 mg, 100 mg, 25 mg
  • Peficitinib [orb1223560]

    >98% (HPLC)

    944118-01-8

    326.3929

    C18H22N4O2

    500 mg, 200 mg, 5 mg, 50 mg, 100 mg, 10 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Peficitinib (orb1300333)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 150.00
25 mg
$ 240.00
50 mg
$ 340.00
100 mg
$ 510.00
200 mg
$ 720.00
DispatchUsually dispatched over 10 weeks
Bulk Enquiry