Peldesine

SKU: orb1309274

Description

Peldesine (BCX-34) is a potent, orally bioavailable, and reversible inhibitor of purine nucleoside phosphorylase. It suppresses T-cell proliferation with an IC50 of 800 nM and has been investigated in preclinical research for cutaneous T-cell lymphoma, psoriasis, and HIV infection.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	133432-71-0
MW	241.25
Purity	99.95% (May vary between batches)
Formula	C₁₂H₁₁N₅O
SMILES	C(C=1C2=C(NC1)C(=O)N=C(N)N2)C=3C=CC=NC3
Target	Nucleoside Antimetabolite/Analog,HIV Protease
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (20.73 mM);DMSO:195 mg/mL (808.29 mM)

Bioactivity

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Target IC50	Proliferation (human T cells):800 nM \|RBC PNP (human):36 nM \|PNP (rat red blood cells):5 nM \|RBC PNP (mouse):32 nM
In Vivo	Peldesine demonstrates oral efficacy by elevating plasma inosine levels in rats (2-fold at 30 mg/kg), significantly reducing ex vivo red blood cell (RBC) purine nucleoside phosphorylase (PNP) activity in rats (98% at 3 hours, 100 mg/kg), and moderately suppressing ex vivo skin PNP activity in mice (39% at 3 hours, 100 mg/kg). Additionally, Peldesine exhibits an oral bioavailability of 76% in rats. Read more...
In Vitro	The IC50s are 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell purine nucleoside phosphorylase, respectively. In Jurkat cells, Peldesine (BCX 34; 0-50 µM; 72 hours) inhibits the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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dGuo, Analog, BCX 34, BCX34, BCX-34, inhibit, IL-2, immunosuppressive, Inhibitor, Nucleoside, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, lymphoma, HIV, HIV Protease, HIVProtease, inosine, Human immunodeficiency virus, phosphorylase, PNP, Peldesine, T-cell, psoriasis, Purine nucleoside phosphorylase

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Compound Identifiers

PubChem CID

135413525 ↗

Key Properties

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No computed properties available.

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Peldesine (orb1309274)

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CAS Number:	2772702-10-8
MW:	314.17
Formula:	C₁₂H₁₃Cl₂N₅O

Peldesine

Description

Research Area

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Key Properties

Bioactivity

Storage & Handling

Alternative Names

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