Perphenazine dihydrochloride

SKU: orb1686926

Description

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2015-28-3
MW	476.89
Purity	99.67%
Formula	C₂₁H₂₈Cl₃N₃OS
SMILES	ClC1=CC=C2SC3=C(N(CCCN4CCN(CC4)CCO)C2=C1)C=CC=C3.Cl.Cl
Target	Dopamine Receptor,Autophagy,Histamine Receptor,5-HT Receptor,Adrenergic Receptor,Apoptosis

Bioactivity

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Target IC50	D3 Receptor:0.43 nM (Ki)\|D4 Receptor:28.5 nM (Ki)\|5-HT1A Receptor:421 nM (Ki)\|5-HT2C Receptor:132 nM (Ki)\|5-HT6 Receptor:17 nM (Ki)\|5-HT7 Receptor:23 nM (Ki)\|D2 Receptor:0.56 nM (Ki)\|5-HT2A Receptor:5.6 nM (Ki) Read more...
In Vivo	In ICR mice, Perphenazine dihydrochloride ( 10, 30, 60, 120, 180 mg / kg ; oral gavage, every other day for 21 days ) increased histological injury and aminotransferases compared with control. Read more...
In Vitro	In L02 cells, Perphenazine dihydrochloride ( 10-100 μM ; 12,24,48 h ) could inhibit cell viability in a concentration and time-dependent manner.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Histamine Receptor, HistamineReceptor, Dopamine Receptor, DopamineReceptor, D3, D2, 5HTReceptor, 5HT Receptor, 5-HT2A, Apoptosis

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Compound Identifiers

PubChem CID

74835 ↗

Key Properties

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No computed properties available.

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