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PF-06263276

SKU: orb1706817

Description

PF-06263276 is a potent and selective pan-JAK inhibitor, demonstrating IC50 values of 2.2 nM (JAK1), 23.1 nM (JAK2), 59.9 nM (JAK3), and 29.7 nM (TYK2). This small molecule is a valuable research tool for investigating JAK/STAT signaling in autoimmune and inflammatory disease models, both in cellular and preclinical studies.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1421502-62-6
MW566.63
FormulaC31H31FN8O2
SMILESCCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CCN(Cc2[nH]1)C(=O)c1cnc(cn1)N1CCCCC1
TargetSTAT,Others,JAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

PF-06263276 (orb1706817)

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