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PHA 543613

SKU: orb1704236

Description

PHA 543613 is a potent and selective α7 nicotinic acetylcholine receptor agonist with a Ki of 8.8 nM. This compound is a valuable research tool for investigating the role of α7 nAChR in cognitive function, supporting in vitro and in vivo studies relevant to Alzheimer's disease and schizophrenia.

Research Area

Metabolism Research, Neuroscience

Images & Validation

Key Properties

CAS Number478149-53-0
MW271.31
Purity99.00% (May vary between batches)
FormulaC15H17N3O2
SMILESO=C(N[C@H]1CN2CCC1CC2)c1cc2ccoc2cn1
TargetAChR
SolubilityDMSO:225 mg/mL (829.31 mM);H2O:< 30.78 mg/mL

Bioactivity

Target IC50
α7 nAChR:8.8 nM (Ki)
In Vivo
In rats, PHA-543613 (0.3 mg/kg) reverses Scopolamine-induced short-term memory deficits. Intraperitoneal injection of PHA-543613 (4 and 12 mg/kg) increases p-Akt and decreases p-GSK-3 and CC3 expressions in the ipsilateral hemisphere. PHA-543613 reduces neuronal cell death in the perihematomal area.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PHA 543613, PHA 543613 hydrochloride, PHA543613, PHA-543613, α7 nAChR

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Key Properties

No computed properties available.

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Protocol Information

PHA 543613 (orb1704236)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 150.00
5 mg
$ 150.00
10 mg
$ 220.00
25 mg
$ 440.00
50 mg
$ 720.00
100 mg
$ 1,040.00
500 mg
$ 2,200.00
DispatchUsually dispatched within 3-5 working days
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