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Phanginin A

SKU: orb1744452

Description

Phanginin A, a natural compound from Caesalpinia sappan, activates SIK1 and inhibits hepatic gluconeogenesis by suppressing the cAMP/PKA/CREB pathway via PDE4 activation. It has demonstrated efficacy in improving metabolic parameters in ob/ob mouse models, making it a useful research tool for studying type 2 diabetes and related metabolic disorders.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1011528-58-7
MW360.44
Purity95.54%
FormulaC21H28O5
SMILESO[C@H]1[C@@]23[C@]([C@@](C(OC)=O)(CO1)CCC2)(CC[C@@]4([C@@]3(CC5=C([C@@H]4C)C=CO5)[H])[H])[H]
TargetSIK

Bioactivity

In Vivo
In the type 2 diabetes ob/ob mouse model, a single oral administration of Phanginin A (100 mg/kg) demonstrated anti-Vitis vinifera ketone effects . Continuous once-daily oral administration of Phanginin A (100 mg/kg) for 26 days effectively improved metabolic parameters in ob/ob mice .
In Vitro
In primary mouse hepatocytes, Phanginin A (5, 10 µM, 0-120 minutes) inhibited p-CREB expression in a time- and dose-dependent manner, while Phanginin A (2.5, 5, 10 µM, 0-120 minutes) promoted p-SIK1 expression in a time- and dose-dependent fashion .

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Phanginin A (orb1744452)

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100 mg
5 mg
$ 1,440.00
10 mg
$ 1,870.00
50 mg
$ 3,730.00