Phloretin

SKU: orb1304838

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Description

Phloretin (NSC-407292) is a natural dihydrochalcone and a potent inhibitor of eukaryotic urea transporters, notably blocking VacA-mediated transport. It exhibits strong antioxidative properties and has demonstrated in vitro efficacy in inhibiting proliferation and inducing apoptosis in various cancer cell lines, including B16 melanoma and HL60 leukemia cells.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	60-82-2
MW	274.27
Purity	>99.99% (May vary between batches)
Formula	C₁₅H₁₄O₅
SMILES	C(CCC1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2O
Target	transporter,Endogenous Metabolite,Urea Transporter,SGLT
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.03 mM);Ethanol:48 mg/mL (175.01 mM);DMSO:80 mg/mL (291.68 mM)

Bioactivity

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In Vitro

Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dihydronaringenin, NSC407292, NSC-407292, NSC 407292, inhibit, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, GLUT, Glucose transporter, Sodium-dependent glucose cotransporters, RJC 02792, RJC02792, RJC-02792, Phloretin, SGLT1, SGLT, SGLT2

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Compound Identifiers

PubChem CID

4788 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

CAS Number:	2058292-99-0
MW:	612.584
Formula:	C₃₁H₃₂O₁₃

MW:	598.554
Formula:	C₂₇H₃₄O₁₅

CAS Number:	3850-43-9
MW:	223.23
Formula:	C₁₁H₁₃NO₄

Purity:	>98% (HPLC)
CAS Number:	60-82-2
MW:	274.28
Formula:	C₁₅H₁₄O₅

Purity:	>98% (HPLC)
CAS Number:	446-71-9
MW:	302.28
Formula:	C₁₆H₁₄O₆

Phloretin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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