Phlorizin

SKU: orb1304840

Description

Phlorizin is a natural, non-selective SGLT inhibitor isolated from apple, exhibiting inhibitory activity against hSGLT1 (Ki=300 nM) and hSGLT2 (Ki=39 nM). It is widely used in research to study glucose transport mechanisms in renal physiology and diabetes, both in vitro and in animal models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	60-81-1
MW	436.41
Purity	99.73%
Formula	C₂₁H₂₄O₁₀
SMILES	C(CCC1=CC=C(O)C=C1)(=O)C2=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C2O
Target	ATPase,SGLT
Solubility	DMSO:118 mg/mL (270.39 mM);Ethanol:43.6 mg/mL (99.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.17 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50	SGLT1 (human):300 nM(Ki)\|SGLT2 (human):39 nM(Ki)
In Vivo	In the treatment of diabetes, obesity, and stress-induced hyperglycemia, Phlorizin exerts its therapeutic effects by inhibiting the sodium-glucose cotransporters located in the proximal renal tubules and the intestinal mucosa. This inhibition results in renal glucosuria and impedes the absorption of glucose in the intestines. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, NSC 2833, Na+/K+ ATPase, NSC2833, NSC-2833, Floridzin, Inhibitor, hSGLT1, hSGLT2, Sodium potassium pump, Sodium-dependent glucose cotransporters, Phlorizin, Phloridzin, SGLT

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Compound Identifiers

PubChem CID

6072 ↗

Key Properties

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No computed properties available.

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Phlorizin (orb1304840)

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Reactivity:	Rat
Dynamic Range:	0.32-20 ng/mL
Sensitivity:	0.121 ng/mL

Reactivity:	Human
Dynamic Range:	0.32-20 ng/mL
Sensitivity:	0.122 ng/mL

Applications:	WB
Predicted Reactivity:	Bovine, Canine, Equine, Human, Porcine, Rabbit, Rat, Sheep
Reactivity:	Mouse
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Reactivity:	Human
Dynamic Range:	0.32-20 ng/mL
Sensitivity:	0.121 ng/mL

Reactivity:	Rat
Dynamic Range:	0.32-20 ng/mL
Sensitivity:	0.124 ng/mL

Phlorizin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Key Properties

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Phlorizin (orb1304840)

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