Phorbol 12-myristate 13-acetate

SKU: orb1296136

Description

Phorbol 12-myristate 13-acetate (PMA) is a natural phorbol ester that acts as an activator of PKC, SphK, and NF-κB, and is commonly used to induce differentiation of THP-1 cells and establish dermatitis models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

Customer Validated Data

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The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this antibody works for your specific application or species, even if we haven't tested it ourselves.

Success by Application

Reactivity Distribution

Latest Experiments

5 Results

Dilution

Sample

Summary

Cell culture

Human

1 µM

C28/I2 cell line

C28/I2 cells were treated with a...

Cell culture

Mouse

50 ng/mL

Naive CD4⁺ T cells isolated from the spleens of adult mice.

Naive CD4⁺ T cells were first...

Cell culture

Human

iPSC-derived NK (iNK) cells

1×10⁶ iNK cells are seeded and...

Induce cell differentiation

Human

100 ng/mL

THP-1 human leukemia monocytic cell line

THP-1 cells are cultured and treated...

Cell culture

Mouse

5 ng/mL

T cells isolated from both the spleen and tumor tissues of C57BL/6J mice

Isolated T cells are incubated in...

Images & Validation

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Key Properties

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CAS Number	16561-29-8
MW	616.83
Purity	99.58%
Formula	C₃₆H₅₆O₈
SMILES	[H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCCCCCC)[C@@]1(OC(C)=O)C2(C)C
Target	PKC,NF-κB,S1P Receptor
Solubility	DMSO: 60 mg/mL (97.27 mM), Sonication is recommended. H2O: Insoluble

Storage & Handling

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Storage	keep away from direct sunlight,store under nitrogen,store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Protein kinase C, S1PReceptor, S1P Receptor, TPA, SphK, Sphingosine kinase, PKC, Phorbol 12 myristate 13 acetate, Phorbol 12-myristate, Phorbol 12myristate 13acetate, Phorbol 12-myristate 13-acetate, Phorbol myristate, Nuclear factor-kappaB, Nuclear factor-κB, PMA, NFκB, NF-κB, NFkB, NF-kB, Inhibitor, inhibit

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Quick Database Links

Gene Symbol

PKC,NF-κB,S1P Receptor

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