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PI3K-IN-1

SKU: orb1226480

Description

PI3K-IN-1 is a potent inhibitor of PI3K, extracted from patent WO2012103524 A2 and WO2013147649 A2.(In Vitro):PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways. By using the PI3K inhibitor PI3K-IN-1, TGF-β1 induced transformation into myofibroblast is also inhibited, with relatively reduced expressions of α-SMA, Col-1 and Timp-1.

Images & Validation

Key Properties

CAS Number1349796-36-6
MW599.6569
Purity>98% (HPLC)
FormulaC31H29N5O6S
SMILESO=C(NC1=CC=C(S(=O)(NC2=NC3=CC=CC=C3N=C2NC4=CC(OC)=CC(OC)=C4)=O)C=C1)C5=CC=C(C)C(OC)=C5
TargetPI3K
SolubilityDMSO: 27.5 mg/mL

Bioactivity

In Vitro
PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways. By using the PI3K inhibitor PI3K-IN-1, TGF-β1 induced transformation into myofibroblast is also inhibited, with relatively reduced expressions of α-SMA, Col-1 and Timp-1.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SAR245409 | Voxtalisib

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PI3K-IN-1 (orb1226480)

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Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 120.00
10 mg
$ 180.00
25 mg
$ 330.00
50 mg
$ 450.00
100 mg
$ 710.00
500 mg
$ 1,540.00