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Picroside IV

SKU: orb1684315

Description

Picroside IV, a catalpol-derived iridoid glycoside from Picrorhiza scrophulariiflora, exhibits diverse pharmacological activities such as neuroprotection and anti-inflammatory effects. It is a valuable research compound for in vitro and in vivo studies in neuroscience, oncology, and metabolic disease research.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number211567-04-3
MW508.47
Purity99.92% (May vary between batches)
FormulaC24H28O12
SMILESC(O)[C@@]12[C@@](O1)([C@@H](O)[C@]3([C@@]2([C@H](O[C@@H]4O[C@H](COC(/C=C/C5=CC=C(O)C=C5)=O)[C@@H](O)[C@H](O)[C@H]4O)OC=C3)[H])[H])[H]
TargetHBV
SolubilityDMSO:80 mg/mL (157.33 mM)

Bioactivity

In Vitro
The pharmacokinetic results indicated that the six components (picroside I, picroside II, vanillic acid, androsin, cinnamic acid, and Picroside IV) in TGPR could be quickly absorbed and slowly eliminated. Their bioavailability was less than 12.37%, indicating poor absorption after intragastric dosing. For tissue distribution, the six components in TGPR were detected in the liver, and only androsin could penetrate the blood-brain barrier. Meanwhile, the excretion study demonstrated that vanillic acid was mostly excreted as prototype drugs, and the remaining five components might be widely metabolized in vivo as the metabolites; the unconverted form was excreted mainly by the feces route .

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Picroside IV
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Key Properties

No computed properties available.

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Protocol Information

Picroside IV (orb1684315)

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Available Sizes

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1 mg
$ 130.00
5 mg
$ 270.00
10 mg
$ 390.00
25 mg
$ 630.00
50 mg
$ 880.00
100 mg
$ 1,170.00
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