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PIM1 Antibody

SKU: orb38744

Description

Rabbit polyclonal antibody to PIM1 or pim-1 whose expression can be detected in the blood cells but it is majorly expressive in the erythrocytes. It is found in the nucleus. It can perform functions like apoptotic processes and shows oncogenic activity through: the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). It also acts as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

Research Area

Cancer Biology, Signal Transduction

Images & Validation

Tested ApplicationsIHC-P, WB
Dilution RangeWB - 1:1000, IHC-P - 1:10-50
ReactivityHuman

Key Properties

Antibody TypePrimary Antibody
HostRabbit
ClonalityPolyclonal
IsotypeRabbit IgG
Clone No.BTD37808
ImmunogenRecombinant Protein
TargetPIM1
Molecular Weight35686
ConjugationUnconjugated

Storage & Handling

StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Form/AppearancePurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

anti-Oncogene PIM 1 antibody, anti-Oncogene PIM1 antibody, anti-PIM 1 antibody, anti-pim 1 kinase 44 kDa isoform antibody, anti-Pim 1 kinase antibody, anti-pim 1 oncogene (proviral integration site 1) antibody, anti-Pim 1 oncogene antibody, anti-PIM antibody, anti-PIM1 antibody, anti-pim1 kinase 44 kDa isoform antibody, anti-Proto oncogene serine/threonine protein kinase Pim 1 antibody, anti-Proto-oncogene serine/threonine-protein kinase Pim-1 antibody, anti-Proviral integration site 1 antibody

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PIM1 Antibody

Western blot analysis of PIM1 (arrow) using PIM1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PIM1 gene (Lane 2).

PIM1 Antibody

Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with PIM1 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

UniProt Details

No UniProt data available

NCBI Reference Sequences

Associated Accession Numbers
Curated reference sequences for the gene transcript and protein product

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Protocol Information

WB
Western Blot (IB, immunoblot)
View Protocol
IHC-P
Immunohistochemistry Paraffin
View Protocol

PIM1 Antibody (orb38744)

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Available Sizes

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50 μl
$ 170.00
100 μl
$ 310.00
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