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Pinostilbene

SKU: orb1222272

Description

Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.

Images & Validation

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Pinostilbene

Key Properties

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CAS Number42438-89-1
MW242.27
Purity>98% (HPLC)
FormulaC15H14O3
SMILESCOc1cc(cc(c1)O)/C=C/c1ccc(cc1)O
TargetOthers
SolubilityIn Vitro: DMSO : 33.33 mg/mL (137.57 mM)

Bioactivity

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In Vitro
Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells. Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells. Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells. Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis. Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Cell Viability Assay Cell line: HCT116 cells, HT29 cells. Concentration: 24 hours, 48 hours. Incubation time: 0-100 μM. Result: Inhibited the growth of two human colon cancer cells. Apoptosis Analysis Cell line: HCT116 cells, HT29 cells. Concentration: 20 μM, 40 μM. Incubation time: 24 hours, 48 hours. Result: Caused a significant and dose-dependent increase in the percentage of cells in S phase. Cell Viability Assay Cell line: HCT116 cells. Concentration: 20 μM, 40 μM. Incubation time: 24 hours, 48 hours. Result: Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21Cip1/Waf1, while decreased the expression levels of cyclin E and p-Rb.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

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  • Pinostilbene

    Pinostilbene [orb1303793]

    99.68% (May vary between batches)

    42438-89-1

    242.27

    C15H14O3

    1 mg, 5 mg, 50 mg, 10 mg, 25 mg, 1 ml x 10 mM (in DMSO)
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