Pinosylvic acid

SKU: orb2893726

Description

Pinosylvic acid, a derivative of the bioactive stilbene pinosylvin, acts as a competitive inhibitor of lunularic acid decarboxylase. This small molecule is utilized in research areas such as plant physiology and biochemistry, particularly in studies investigating enzyme inhibition and the biosynthesis of related compounds in vitro.

Images & Validation

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Key Properties

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CAS Number	38232-09-6
MW	256.25
Formula	C₁₅H₁₂O₄
SMILES	C(=C/C1=CC=CC=C1)\C2=C(C(O)=O)C(O)=CC(O)=C2
Target	Others

Bioactivity

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In Vivo

In inflammation and cardiovascular disease in vivo experimental models in rats or mice, Pinosylvic acid (at doses of 10-50mg/kg) was administered via oral or intraperitoneal injection for a duration of 14-28 days. The Results showed that Pinosylvic acid significantly reduced MPO activity and levels of inflammatory markers such as TNF-α. In cardiovascular disease models, it effectively improved myocardial function and alleviated myocardial damage. Histological analysis revealed that Pinosylvic acid could reduce infiltration of inflammatory cells and tissue damage. The study confirmed that Pinosylvic acid exhibited significant anti-inflammatory effects in vivo, provided protective effects against cardiovascular diseases, and showed no apparent toxicity or side effects during the experiment, indicating good safety.

In Vitro

Pinosylvic acid (10µM, 20µM, 50µM) was used to treat RAW264.7 macrophages, and after LPS-induced inflammation, various Methods including the Griess assay, quantitative PCR, Western blotting, and immunofluorescence were employed for detection. The Results showed that Pinosylvic acid (10-50µM) significantly inhibited LPS-induced NO production (P<0.001), reduced the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α, and inhibited the nuclear translocation of NF-κBp65. These findings suggest that Pinosylvic acid exhibits significant anti-inflammatory activity in vitro by inhibiting the NF-κB signaling pathway .

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Pinosylvicacid.

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Compound Identifiers

PubChem CID

9813767 ↗

Key Properties

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No computed properties available.

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Pinosylvic acid

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Pinosylvic acid (orb2893726)

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