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PKM2 agonist-1

SKU: orb3174918

Description

PKM2 agonist-1 (Compound D16) is a potent allosteric activator of PKM2, with an AC50 value of 77 nM. It inhibits angiotensin II-induced smooth muscle cell phenotypic transformation, effectively preventing aortic dissection and reducing mortality.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number3075162-42-1
MW509.6
FormulaC24H23N5O4S2
SMILESO=S(=O)(NC=1C=CC(=CC1)C2=NC=CN2C3CN(C3)S(=O)(=O)C4CC4)C5=CC=CC6=CC=CN=C65
TargetPKM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information