Plantainoside D

SKU: orb1301482

Description

Plantainoside D (Isoplantamajoside) is a bioactive small molecule with potent antioxidant activity comparable to ascorbic acid. It functions as an in vitro ACE inhibitor (IC50 = 2.17 mM) and a PKCα inhibitor (IC50 = 14.8 µM), making it a compound of interest for cardiovascular and signal transduction research.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	147331-98-4
MW	640.59
Purity	99.97% (May vary between batches)
Formula	C₂₉H₃₆O₁₆
SMILES	OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](COC(=O)\C=C\c3ccc(O)c(O)c3)O[C@@H](OCCc3ccc(O)c(O)c3)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
Target	IκB/IKK,Angiotensin-converting Enzyme (ACE),ROS,Calcium Channel,PKC,NOD-like Receptor (NLR),NF-κB,Apoptosis,RAAS,Sirtuin
Solubility	H2O:10 mg/mL (15.61 mM);DMSO:55 mg/mL (85.86 mM)

Bioactivity

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Target IC50

ACE:2.17 mM |PKC:14.8microM

In Vitro

Plantago asiatica L. and its major constituents(such as Plantainoside D) have ACE inhibitory activity in vitro. The identified compounds contribute to the angiotensin-converting enzyme-inhibitory activity of the extract.In vitro, Adriamycin(ADR) caused dose-dependent toxicity in H9c2 cardiac muscle cells. Pre-treatment of the cardiac muscle cells with Plantainoside D(PD) significantly reduced ADR-induced apoptosis of cardiac muscle cells. PD inhibited the ROS produced by ADR in the cardiac muscle cells. As well, PD increased GSH(glutathione), compared with ADR. In response to ADR, NF-kappaB was activated in H9c2 cells. However the treatment of PD reduced the activation of NF-kappaB.The NF-kappaB inhibitor, PDTC, inhibited the cytotoxic effect on ADR-induced apoptosis in cardiac muscle cells. IkappaBalpha-dominant negative plasmid-overexpression abrogated ADR-induced apoptosis in H9c2 cardiac muscle cells.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Angiotensin-converting Enzyme (ACE), ACE, inhibit, Isoplantamajoside, IκB kinase, IKK, Inhibitor, I kappa B kinase, PKC, Plantainoside D

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Compound Identifiers

PubChem CID

9986606 ↗

Key Properties

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No computed properties available.

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Plantainoside D (orb1301482)

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Purity:	>98% (HPLC)
CAS Number:	147331-98-4
MW:	640.6
Formula:	C₂₉H₃₆O₁₆?

Plantainoside D

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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