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Platycodin D

SKU: orb1222008

Description

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.

Images & Validation

Key Properties

CAS Number58479-68-8
MW1225.34
Purity>98% (HPLC)
FormulaC57H92O28
SMILESC1C(CC[C@@]2([C@@H](C[C@@]3([C@@]4(CC[C@H]5C([C@H]([C@H](C[C@@]5(C4CC=C3[C@H]12)C)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)(CO)CO)C)C)O)C(=O)O[C@@H]1OC[C@@H]([C@@H]([C@H]1O[C@@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O[C@@H]1OC[C@H]([C@@H]([C@H]1O)O[C@@H]1OC[C@@]([C@H]1O)(CO)O)O)C)O)O)(C)C
TargetAChR
SolubilityIn Vitro: DMSO : 50 mg/mL (40.81 mM)

Bioactivity

In Vivo
Animal model: Genetically obese db/db mice. Dosage: 5 mg/kg. Administration: Oral administration; 5 mg/kg, 5 times per week for 5 weeks. Result: Significantly decreased body weight gain without affecting food intake of mice. Decreased the liver tissue weight and increased the weight of brown adipose tissue (BAT).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Platycodin D (orb1222008)

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Available Sizes

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5 mg
$ 100.00
10 mg
$ 150.00
25 mg
$ 230.00
50 mg
$ 340.00
100 mg
$ 540.00
500 mg
$ 1,170.00