Ponsegromab Antibody

SKU: orb1980669

Description

Ponsegromab is a humanized monoclonal antibody that selectively inhibits GDF15 by blocking its interaction with the GFRAL receptor. This mechanism disrupts the associated signaling pathway, offering a potential therapeutic strategy for cancer-associated anorexia and cachexia, as investigated in preclinical research models.

Research Area

Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	2368950-15-4
MW	146.08 kDa
Purity	100% (SEC-HPLC)
Target	TGF-beta/Smad

Bioactivity

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Target IC50	GDF15-GFRAL:0.5037 μg/mL\|GDF15:0.1095 μg/mL (EC50)

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Smad, TGF-beta/Smad, TGFbeta/Smad, TGF-beta, TGFbeta, TGF-b/Smad, TGFb, TGF-β/Smad, TGFβ, Ponsegromab, PF06946860, PF-06946860, PF 06946860

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Gene Symbol

TGF-beta/Smad

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