Pozanicline hydrochloride

SKU: orb1307859

Description

Pozanicline hydrochloride is a selective α4β2 nicotinic acetylcholine receptor agonist with high binding affinity (Ki ~17 nM). It is used in neuroscience research to study receptor function and has been applied in experimental models investigating cognitive and analgesic pathways.

Research Area

Neuroscience

Images & Validation

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Key Properties

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MW	228.72
Purity	97.13% (May vary between batches)
Formula	C₁₁H₁₇ClN₂O
SMILES	[H]Cl.CC1=NC=CC=C1OC[C@H]2NCCC2
Target	AChR
Solubility	DMSO:55 mg/mL (240.47 mM)

Bioactivity

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In Vivo	Pozanicline hydrochloride (0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning.
In Vitro	Pozanicline hydrochloride is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM. Pozanicline hydrochloride shows high selectivity for α6β2 and α4α5β2 nAChR subtypes. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Pozanicline hydrochloride, Pozanicline Hydrochloride, α4β2 nAChR

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Compound Identifiers

PubChem CID

129718535 ↗

Key Properties

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No computed properties available.

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