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PP58

SKU: orb1707865

Description

PP58 is a small molecule inhibitor targeting platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR), and Src family kinases. It is a research tool used in vitro and in vivo to study signaling pathways in oncology and angiogenesis.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number212391-58-7
MW456.32
Purity99.62% (May vary between batches)
FormulaC22H19Cl2N5O2
SMILESCn1c2nc(Nc3ccc(OCCN)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
TargetSrc,TNF,p38 MAPK,PDGFR,FGFR
SolubilityDMSO:56.3 mg/mL (123.38 mM)

Bioactivity

In Vivo
PP58 exhibits some degree of selectivity in vivo.
In Vitro
PP58 inhibits anisomycin-activated p38 in a dose-dependent manner with an IC50 < 10 nM. LPS-stimulated TNF-α production is potently inhibited by PP58 with a cellular IC50 value of 3 nM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FGFR, Src, TNF-α, PP 58, PP58, PP-58, p38 MAPK, p38MAPK, p38, PDGFR

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Key Properties

No computed properties available.

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Protocol Information

PP58 (orb1707865)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 140.00
50 mg
$ 280.00
DispatchUsually dispatched within 3-5 working days
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