PPARδ agonist 11

SKU: orb2665100

Description

Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	2982696-04-6
MW	440.46
Formula	C₁₉H₁₅F₃N₂O₃S₂
SMILES	O=C(O)COC1=CC=C(SCC2=NN=C(S2)C=3C=CC(=CC3)C(F)(F)F)C=C1C
Target	PPAR

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

PPAR

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