Pramipexole

SKU: orb1227067

Description

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Parkinson's Disease Approved.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	104632-26-0
MW	211.3271
Purity	>98% (HPLC)
Formula	C₁₀H₁₇N₃S
SMILES	CCCN[C@H](C1)CCC2=C1SC(N)=N2
Target	Dopamine Receptor
Solubility	10 mM in DMSO

Bioactivity

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In Vivo

Pramipexole (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals. Pramipexole improves neurological recovery. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Animal model: Male Wistar rats weighing 250-300 g (16-18 weeks old). Dosage: 0.25 mg/kg, 1 mg/kg. Administration: Intraperitoneal injection. Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.

In Vitro

Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50, 000 nM. Pramipexole (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size. Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Pramipexole | Oprymea | Pramipexol | Pramipexolum

Quality Guarantee

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Gene Symbol

Dopamine Receptor

Protocol Information

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Purity:	99.68% (May vary between batches)
CAS Number:	191217-81-9
MW:	302.26
Formula:	C₁₀H₁₇N₃S·2HCl·H₂O

Purity:	99.96% (May vary between batches)
CAS Number:	104632-26-0
MW:	211.33
Formula:	C₁₀H₁₇N₃S

CAS Number:	104632-25-9
MW:	247.79
Formula:	C₁₀H₁₈ClN₃S

CAS Number:	1246815-83-7
MW:	253.41
Formula:	C₁₃H₂₃N₃S

CAS Number:	1801892-43-2
MW:	267.39
Formula:	C₁₃H₂₁N₃OS

Pramipexole

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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