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Primin

SKU: orb1297232

Description

Primin is a natural compound isolated from the trichomes of Primula obconica. It exhibits potent antimycobacterial activity and significant antineoplastic properties, making it a candidate for research in infectious disease and oncology. Studies have explored its mechanisms in both in vitro cell-based assays and in vivo experimental models.

Research Area

Infectious Disease & Virology

Images & Validation

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Primin

Key Properties

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CAS Number15121-94-5
MW208.25
Purity99.91% (May vary between batches)
FormulaC12H16O3
SMILESC(CCCC)C=1C(=O)C(OC)=CC(=O)C1
TargetAntibacterial,Antifection
SolubilityDMSO:60 mg/mL (288.12 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (12 mM)

Bioactivity

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Target IC50
Leishmania donovani:0.711 μM|T. brucei rhodesiense:0.144 μM
In Vitro
Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and revealed low cytotoxicity (IC50 15.4 microM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum. When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p. route) in mice infected with L. donovani.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Primula, Primin, inhibit, obconica, Inhibitor, Bacterial, Antifection
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
84800 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 140.00
5 mg
$ 150.00
10 mg
$ 200.00
25 mg
$ 370.00
50 mg
$ 520.00
100 mg
$ 730.00
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