Cart summary

You have no items in your shopping cart.

Primin

SKU: orb1297232

Description

Primin is a natural compound isolated from the trichomes of Primula obconica. It exhibits potent antimycobacterial activity and significant antineoplastic properties, making it a candidate for research in infectious disease and oncology. Studies have explored its mechanisms in both in vitro cell-based assays and in vivo experimental models.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number15121-94-5
MW208.25
Purity99.91% (May vary between batches)
FormulaC12H16O3
SMILESC(CCCC)C=1C(=O)C(OC)=CC(=O)C1
TargetAntibacterial,Antifection
SolubilityDMSO:60 mg/mL (288.12 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (12 mM)

Bioactivity

Target IC50
Leishmania donovani:0.711 μM|T. brucei rhodesiense:0.144 μM
In Vitro
Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and revealed low cytotoxicity (IC50 15.4 microM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum. When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p. route) in mice infected with L. donovani.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Primula, Primin, inhibit, obconica, Inhibitor, Bacterial, Antifection

Similar Products

  • Primin (Standard) [orb3140899]

    15121-94-5

    208.25

    C12H16O3

    10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Primin (orb1297232)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 140.00
5 mg
$ 150.00
10 mg
$ 200.00
25 mg
$ 380.00
50 mg
$ 540.00
100 mg
$ 770.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry