PROCYANIDIN C1

SKU: orb1297231

Description

Procyanidin C1 is a natural polyphenol compound that induces apoptosis in cancer cells through DNA damage and cell cycle arrest, mediated by the downregulation of Bcl-2 and upregulation of BAX, caspase-3, and caspase-9. It is widely used in vitro and in vivo for research in oncology, chemoprevention, and apoptosis signaling pathways.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	37064-30-5
MW	866.77
Purity	99.86%
Formula	C₄₅H₃₈O₁₈
SMILES	O[C@@H]1Cc2c(O)cc(O)c([C@@H]3[C@@H](O)[C@H](Oc4c([C@@H]5[C@@H](O)[C@H](Oc6cc(O)cc(O)c56)c5ccc(O)c(O)c5)c(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1
Target	Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.81 mM);DMSO:90.14 mg/mL (104 mM)

Bioactivity

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In Vivo

METHODS: DLD1 and SW1463 cells were injected into the right axilla of BALB/c nude mice. The nude mice were treated with Procyanidin C1 (20 mg/kg and 40 mg/kg, intraperitoneal injection, once every three days), and the tumor volume and tumor weight were calculated. METHODS: Procyanidin C1 can inhibit tumor growth and metastasis in CRC, and the has-miR-501-3p/HIGD1A axis is involved in this process.

In Vitro

METHODS: PSC27 cells were treated with Procyanidin C1 (5, 10, 25, 50, 100, 400 μM) and senescent PSC27 cell survival was measured by SA-β-Gal staining. RESULTS Procyanidin C1 exerted an anti-senescent effect on senescent stromal cells starting at a concentration of 50 μM, at which concentration proliferating cells were largely unaffected. METHODS: Procyanidin C1 (5 and 10 μM) was used in DLD1 and HCT116 cells, and the expression of has-miR-501-3p was detected. RESULTS Procyanidin C1 inhibited the expression of has-miR-501-3p in CRC cells with increasing concentrations.

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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PCC 1, PCC1, PCC-1, inhibit, Inhibitor, Apoptosis protein, Apoptosis, Procyanidin C 1, PROCYANIDIN C1, PROCYANIDIN C-1

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Compound Identifiers

PubChem CID

169853 ↗

Key Properties

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No computed properties available.

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PROCYANIDIN C1

Description

Research Area

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Key Properties

Bioactivity

Storage & Handling

Alternative Names

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PROCYANIDIN C1 (Standard) [orb3140922]

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