Prolyl-4-hydroxylase Inhibitor 11

SKU: orb1741453

Description

2,2'-Bipyridine-5,5'-dicarboxylic acid

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1802-30-8
MW	244.2
Purity	99.76% (May vary between batches)
Formula	C₁₂H₈N₂O₄
SMILES	OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O
Target	Others
Solubility	DMSO:0.97 mg/mL (3.97 mM)

Bioactivity

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Target IC50	Prolyl hydroxylase:0.19 microM
In Vivo	In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). The in vivo experiments showed that the production of reactive oxygen species in C. pyrenoidosa treated by the addition of Bpy-COOH and Cu(II) in three orders were all significantly less than that in cases treated with only Cu(II).
In Vitro	In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). In vitro tests indicated that peroxidase-like complexes could be formed between Bpy-COOH and Cu(II). It could be concluded that the use of Bpy-COOH could significantly decrease Cu(II) toxicity to algal cells by forming peroxidase-like complexes. Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase. [2,2'-bipyridine]-5,5'-dicarboxylic acid (IC50 = 0.19 microM) is the most potent inhibitor of its type yet reported.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Proline 4-hydroxylase

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Compound Identifiers

PubChem CID

192744 ↗

Key Properties

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No computed properties available.

Protocol Information

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Purity:	>98% (HPLC)
CAS Number:	1802-30-8
MW:	244.2
Formula:	C₁₂H₈N₂O₄

Prolyl-4-hydroxylase Inhibitor 11

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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