PROTAC c-Met degrader-1

SKU: orb2695494

Description

PROTACc-Met degrader-1 (Met-DD4) is an orally active c-Met-targeting PROTAC with a DC50 of 6.21 nM. It potently inhibits proliferation (IC50=4.37 nM) and induces G0/G1 arrest in MKN-45 cells, demonstrating in vivo antitumor efficacy in xenograft models, supporting research in targeted protein degradation and cancer therapeutics.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	3056647-52-7
MW	820.87
Formula	C₄₅H₄₁FN₁₀O₅
SMILES	O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCN(CC4)CC5CCN(C(=O)C=6C=CC(=CC6F)C7=NN8C(N=C7)=NC=C8CC9=CC=C%10N=CC=CC%10=C9)CC5
Target	PROTACs,c-Met/HGFR

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

172652631 ↗

Key Properties

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No computed properties available.

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