PROTAC HDAC6 degrader 7

PROTACHDAC6 degrader7 is an orally active, potent, and selective PROTAC degrader targeting histone deacetylase 6 (HDAC6) with an IC50 of 118 nM. It degrades both the catalytic domain and the zinc finger ubiquitin-binding domain of HDAC6. Furthermore, PROTACHDAC6 degrader7 inhibits the assembly and activation of the NLRP3 inflammasome and blocks the NF-κB signaling pathway, leading to reduced transcription and release of key inflammatory factors. It also decreases the mRNA levels of NLRP3, pro-IL-1β, TNF-α, and IL-6. This compound is useful for research in inflammatory bowel disease (IBD).