PROTAC XPO1 degrader-1

SKU: orb2945221

Description

PROTAC XPO1 degrader-1 (Compound 2c) is a small molecule that selectively degrades XPO1, demonstrating anti-proliferative and pro-apoptotic activity in vitro. It inhibits NF-κB signaling and induces G1 cell cycle arrest, making it a useful research tool for studying hematological malignancies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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MW	734.122
Formula	C₃₃H₃₅ClF₃N₇O₇
SMILES	CC1=C(C(=O)N(C1=O)NC2=NC(=C(C=C2)C(F)(F)F)Cl)CCC(=O)NCC3CCN(CC3)C4=CC=CC(=C4OC)C(=O)NC5CCC(=O)NC5=O
Target	NF-κB,Apoptosis,PROTACs,CRM1

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

172677071 ↗

Key Properties

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No computed properties available.

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