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Proxyphylline

SKU: orb1301392

Description

Proxyphylline is a xanthine derivative functioning as a dual adenosine A1/A2a receptor antagonist and phosphodiesterase inhibitor. It is utilized in research as a bronchodilator, vasodilator, and cardiac stimulant for investigating respiratory and cardiovascular pathways in experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number603-00-9
MW238.24
Purity99.79% (May vary between batches)
FormulaC10H14N4O3
SMILESC(C(C)O)N1C2=C(N(C)C(=O)N(C)C2=O)N=C1
TargetPDE,Adenosine Receptor
SolubilityDMSO:70 mg/mL (293.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.39 mM)

Bioactivity

In Vitro
Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

7-(2-Hydroxypropyl)theophylline, A2A, A1, Adenosine Receptor, AdenosineReceptor, Inhibitor, PDE, inhibit, Proxyphylline, P1 receptor

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  • Proxyphylline [orb1220576]

    >98% (HPLC)

    603-00-9

    238.24

    C10H14N4O3

    1 g, 500 mg
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Key Properties

No computed properties available.

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Proxyphylline (orb1301392)

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1 g
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
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