Pseudoprotodioscin

SKU: orb1222924

Description

Pseudoprotodioscin has moderate cytotoxicity.

Images & Validation

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Key Properties

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CAS Number	102115-79-7
MW	1031.2
Purity	>98% (HPLC)
Formula	C₅₁H₈₂O₂₁
SMILES	CC1C(C(C(C(O1)OC2C(OC(C(C2O)OC3C(C(C(C(O3)C)O)O)O)OC4CCC5(C6CCC7(C(C6CC=C5C4)CC8C7C(=C(O8)CCC(C)COC9C(C(C(C(O9)CO)O)O)O)C)C)C)CO)O)O)O
Target	Others
Solubility	In Vitro: H2O : ≥ 100 mg/mL (96.98 mM)D)

Bioactivity

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In Vitro

In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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