Pulsatilla saponin D

SKU: orb1221543

Description

Pulsatilla saponin D has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer and it inhibits cell growth via cell cycle arrest and apoptosis in various cancer cell types.

Images & Validation

−

Key Properties

−

CAS Number	68027-15-6
MW	913.11
Purity	>98% (HPLC)
Formula	C₄₇H₇₆O₁₇
SMILES	C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](CO[C@H]2O[C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC=C3[C@@H]5CC(C)(C)CC[C@@]5(CC[C@@]43C)C(O)=O)[C@]2(C)CO)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H](O)[C@H]1O
Target	Others
Solubility	DMSO:40 mg/mL

Bioactivity

−

In Vivo

Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model. Animal model: 2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s. c. into the auxiliary region of the BDF1 mice. Dosage: 6.4 mg/kg. Administration: Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. Result: Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).

In Vitro

Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase. Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells. Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC). Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF. Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells. Cell Cytotoxicity Assay Cell line: A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells. Concentration: 0.3 ng/mL to 10 μg/mL. Incubation time: 72 h. Result: Exhibited an ED50 value of 6.3 μg/mL for A-549 cells.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Hederacolchiside A | SB365

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

Others

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols