PUMA BH3 (human) TFA

SKU: orb1980052

Description

PUMA BH3 is a peptide derived from the BH3 domain of PUMA that binds and activates the pro-apoptotic protein Bak, with Kd values of 290 nM (HEPES) and 26 nM (CHAPS). This binding triggers Bak oligomerization and membrane permeabilization, making it a valuable tool for studying apoptosis mechanisms in both in vitro and cell-based assays.

Images & Validation

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Key Properties

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MW	3049.30
Formula	C₁₂₈H₂₀₂N₄₂O₄₃S.XCF₃COOH
SMILES	[H]N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)C)=O)=O)=O)CC(O)=O)=O)CC(O)=O)=O)C)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O.OC(C(F)(F)F)=O

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

171361337 ↗

Key Properties

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No computed properties available.

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